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. 2021 Sep 9;9:714601. doi: 10.3389/fcell.2021.714601

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Copyright © 2021 Ren, Yang, Guo, Huang, Li, Yang and Tian.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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hsa_circ_0000073 enhanced malignant behavior in vitro. (A) qRT-PCR qualified silenced efficiencies of hsa_circ_0000073. (B) qRT-PCR confirmed knockdown and overexpression of hsa_circ_0000073 by shRNA and overexpressing plasmid. (C,D) CCK-8 and clone formation assays showed hsa_circ_0000073 stimulated cell proliferation in OS cells. (E,F) Wound-healing and transwell assays verified hsa_circ_0000073 enhanced migration and invasion ability in OS cells with regulation, magnification, ×200. (G) Flow cytometry analysis revealed that hsa_circ_0000073-silenced induced S phase arrested in OS cells, whereas hsa_circ_0000073-overexpressed reductions. Data were presented as mean ± SD. **P < 0.005, ***P < 0.001.