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. 2021 Sep 9;9:714601. doi: 10.3389/fcell.2021.714601

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Copyright © 2021 Ren, Yang, Guo, Huang, Li, Yang and Tian.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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hsa_circ_0000073 enhanced malignant behavior of OS cells by targeting miR-1252-5p and regulating CCNE2 and MDM2. (A,B) CCK-8 and colony formation assays demonstrated that overexpressed-miR-1252-5p, silenced-CCNE2, or MDM2 restored growth promotion induced by hsa_circ_0000073 overexpression. (C,D) Wound-healing and transwell assays evaluated cell migration and invasion in indicated groups, magnification, ×200. (E) Flow cytometry assay determined cell cycle under diverse conditions. Data were presented as mean ± SD ***P < 0.001.