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. 2021 Sep 9;9:714601. doi: 10.3389/fcell.2021.714601

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Copyright © 2021 Ren, Yang, Guo, Huang, Li, Yang and Tian.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Knockdown of hsa_circ_0000073 represses tumor growth through sponging miR-1252-5p and regulating CCNE2, and MDM2 in vivo. (A) Images, weight and growth curve of tumors after transfection with sh- hsa_circ_0000073 or sh-NC. (B) qRT-PCR determined expression of hsa_circ_0000073, miR-1252-5p, CCNE2, and MDM2 in tumors collected earlier. (C,D) WB and immunohistochemistry evaluated expression of CCNE2 and MDM2 when hsa_circ_0000073 was silenced, magnification, ×200. (E) Schematic illustration of final regulatory circuit among hsa_circ_0000073, miR-1252-5p, CCNE2, and MDM2. Data were presented as mean ± SD ***P < 0.001.