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. 2021 Sep 23;16(9):e0254326. doi: 10.1371/journal.pone.0254326

Table 1. KEGG pathway enrichment analyses for DEGs.

Gender Pathway description P-Value Count
Male Upregulated Sphingolipid signaling pathway 0.000462 7
Biosynthesis of amino acids 0.001856 5
Hepatocellular carcinoma 0.003485 7
Autophagy 0.003942 6
NOD-like receptor signaling pathway 0.014277 6
Downregulated Rheumatoid arthritis 0.000121 5
Chemokine signaling pathway 0.003538 5
Human cytomegalovirus infection 0.007385 5
Cytokine-cytokine receptor interaction 0.021566 5
Female Upregulated Leishmaniasis 0.000008 11
Osteoclast differentiation 0.000076 13
Chemokine signaling pathway 0.000105 16
Renal cell carcinoma 0.000148 9
Hepatitis B 0.000252 13
Systemic lupus erythematosus 0.000437 12
Kaposi sarcoma-associated herpesvirus infection 0.000937 14
Autophagy 0.001133 11
Human immunodeficiency virus 1 infection 0.001169 15
Phagosome 0.001433 12
Downregulated Natural killer cell mediated cytotoxicity 3.85E-07 13
Antigen processing and presentation 0.000366 7
Graft-versus-host disease 0.000680 5
Th1 and Th2 cell differentiation 0.001076 7
NF-kappa B signaling pathway 0.001300 7
T cell receptor signaling pathway 0.001856 7
Sphingolipid signaling pathway 0.004458 7
Hematopoietic cell lineage 0.006826 6
HIF-1 signaling pathway 0.007894 6
Overlap Upregulated Platelet activation 0.000410 5
Downregulated Structural constituent of ribosome 0.000097 6
DNA-binding transcription activator activity, RNA polymerase II-specific 0.001188 8
RNA polymerase II proximal promoter sequence-specific DNA binding 0.002694 8
proximal promoter sequence-specific DNA binding 0.003296 8