Table 7. The median survival and objective response rate of prospective and retrospective studies applying radiotherapy in HCC with PVTT.

Studies	Year	Design	Treatment	No.	OR	Median survival (months)
						All	Responder	Non-responder	P value
Tazawa et al. [10]	2001	Retrospective	TACE + RT	24	50%	12.5 (A) 2.7 (B)	9.7	3.8	< 0.001
Ishikura et al [11]	2002	Prospective	TACE + RT	20	50%	5.3	NA	NA	NA
Yamada et al. [12]	2003	Prospective	TACE + RT	19	57.9%	7	15.4	4.6	0.16
Kim et al. [13]	2005	Retrospective	RT	59	45.8%	10.7	10.7	5.3	0.05
Nakazawa et al. [15]	2007	Retrospective	RT	32	48%	5.7	13.8	7.0	0.01
Toya et al. [8]	2007	Retrospective	RT	38	44.7%	9.6	NA	NA	NA
Zeng et al. [7]	2008	Retrospective	RT	136	57.6%	9.7	19.5(CR) 10.2(PR)	7.2 (SD) 3.5 (PD)	< 0.001
Yu et al. [9]	2011	Retrospective	RT ± TACE	281	53.8%	11.6	22.0	5.0	< 0.001
Yoon et al. [16]	2012	Retrospective	TACE + RT	412	39.6%	10.6	19.4	7.0	< 0.001
Kim et al. [18]	2014	Retrospective	TACE + RT	59	51.0%	17	NA	NA	NA
This study	2021	Retrospective	RT	160	74.0%	8.3	13.1	6.8	0.002