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. Author manuscript; available in PMC: 2021 Sep 23.
Published in final edited form as: ACS Appl Nano Mater. 2020 Jun 15;3(7):7211–7222. doi: 10.1021/acsanm.0c01553

Figure 3.

Figure 3.

TEM imaging of QDs, sEVs, and QD-sEVs. (A) QDs, sEVs, and QD-sEVs conjugates were imaged using TEM. QDs alone (left panel), sEVs alone (middle panel), and QD-sEV conjugates (right panel) were presented. QDs on the surface of sEVs are pointed out by white arrows. A magnified TEM image further indicates colocalization of QDs and sEVs at the single EV level (right insert). Scale bar: 100 nm in left panel, 200 nm in middle and right pane, and 100 nm in right insert. (B) QDs were conjugated to sEVs using click chemistry in varying ratios of QD to sEV and imaged using TEM. QD:sEV ratios of 40:1 (left), 70:1 (middle), 100:1 (right) were evaluated. Altering QD:sEV ratio changes the uniformity of QD distribution on the sEV surface. White arrows point to QDs on the surface of sEVs. Scale bars: 100 nm in left panel, 200 nm in middle and right panel.