TABLE 3.
Unadjusted and adjusted delivery outcomes
| Delivery outcome: sPTB rate | 17-OHPC (n=21) | No 17-OHPC (n=38) | P value | OR | Adjusted ORa |
|---|---|---|---|---|---|
| sPTB <34 wk | 16(73) | 24 (63) | .45 | 1.56(0.49–4.90) | 1.75 (0.48–6.39) |
| sPTB <32 wk | 9(41) | 16(42) | .93 | 0.95 (0.33–2.77) | 0.84 (0.25–2.84) |
| sPTB <28 wk | 5(23) | 10(26) | .76 | 0.82 (0.24–2.82) | 1.59 (0.59–4.25) |
| sPTB <24 wk | 3(14) | 7(18) | .63 | 0.70(0.16–3.04) | 0.47(0.10–2.19) |
| Delivery outcome: overall PTB rate | 17-OHPC (n=27) | No 17-OHPC (n=52) | P value | OR | Adjusted ORa |
| sPTB <34 wk | 17(63) | 27 (52) | .35 | 1.57(0.61–4.08) | 2.69 (0.85–8.54) |
| sPTB <32 wk | 9(33) | 18(35) | .91 | 0.94 (0.35–2.52) | 1.02 (0.33–3.13) |
| sPTB <28 wk | 5(19) | 11 (21) | .78 | 0.85 (0.26–2.75) | 0.67(0.16–2.76) |
| sPTB <24 wk | 3(11) | 7(14) | .76 | 0.80(0.19–3.39) | 0.79(0.16–3.85) |
| Delivery outcome: neonatal | 17-OHPC (n=54) | No 17-OHPC (n=104) | P value | OR | Adjusted ORa |
| Composite neonatal morbidity and mortality (y/n) | 38 (70) | 77 (74) | .62 | 0.83 (0.40–1.73) | 1.54 (0.63–3.74) |
Delivery outcomes among patients with twin pregnancy and prior spontaneous preterm birth treated with 17-alpha-hydroxyprogesterone caproate vs those not treated with 17-alpha-hydroxyprogesterone caproate.
Data are expressed as n (%) or odds ratio (95% confidence interval). P value for 2-sided Pearson chi-square analysis.
17-OHPC, 17-alpha-hydroxyprogesterone caproate; OR, odds ratio; PTB, preterm birth; sPTB, spontaneous preterm birth.
a
Adjusted for maternal age, race, and number of prior spontaneous preterm births.
Ward et al. 17-OHPC in twins and prior preterm birth. AJOG MFM 2020.