FIG. 2.
(A) ASC-1 amino acid sequence. Two potential nuclear localization signals are underlined. Cysteine and histidine residues are indicated in boldface (those conserved with E1A [14] and VAC1 [51] are underlined). The positions of the deletions in ASCΔN and ASCΔNΔC are indicated by arrows. (B) Schematic diagram of ASC-1 and its deletion mutants. The putative zinc finger domain is as indicated. ASCΔN consists of the ASC-1 residues 125 to 581, and ASCΔNΔC includes only the putative zinc finger domain (residues 125 to 237). The zinc finger region is specifically deleted in ASCdn (i.e., the ASC-1 residues 165 to 216).