Table 1.
RNAi clones that improved movement in C. elegans models of Huntington’s disease.
| Target gene | Drosophila homolog | Mammalian homolog | Effect on crawling BW-Htt74Q |
Effect of crawling BW-Htt28Q |
Effect on thrashing BW-Htt74Q | Effect of thrashing BW-Htt28Q |
Effect on aggregation |
|---|---|---|---|---|---|---|---|
| drp-1 | Drp1 | DNM1L | No effect | No effect | No effect | No effect | Decreased |
| sdha-2 | SdhA | SdhA | Increased | Increased | No effect | Decreased | No effect |
| C34B2.8 | ND-B16.6 | NDUFA13 | Increased | No effect | Decreased | No effect | No effect |
| gpd-4 | Gapdh2 | GAPDH | Increased | No effect | No effect | Decreased | No effect |
| F25B5.6 | Fpgs | FPGS | Increased | No effect | Increased | No effect | No effect |
| oatr-1 | Oat | OAT | Increased | Increased | No effect | No effect | No effect |
| alh-12 | Aldh | ALDH9A1 | Increased | No effect | Increased | Decreased | No effect |
| R10H10.6 | CG2846 | RFK | Increased | No effect | No effect | No effect | No effect |
| dlat-2 | muc | DLAT | Increased | Decreased | No effect | Decreased | No effect |
| pgp-3 | Mdr49 | ABCB4 | Increased | No effect | Increased | Decreased | No effect |
| wht-1 | w | ABCG1 | Increased | No effect | No effect | No effect | No effect |
| gpx-1 | PHGPx | GPX4 | No effect | No effect | Increased | No effect | No effect |
| immt-2 | Mitofilin | IMMT | No effect | No effect | Increased | No effect | No effect |