Table 2.

Molecular tests.

Variable	(a) Young adults (18-39 y.o.) N=29, M=13, W=16	(b) Adults (40-64 y.o.) N=40, M=21, W=19	(c) Older adults (65-89 y.o.) N=54, M=28, W=26	(d) Nonagenarians (90-99 y.o.) N=27, M=9, W=18	(e) Centenarians (100-111 y.o.) N=23, M=6, W=17	Age	Interaction		Gender
							M	W
RTL
	1.19 (0.91-1.80) N=29, (1.20±0.21) M=13, (1.11±0.18) W=16, (1.28±0.20)	1.04 (0.60-1.51) N=38, (1.02±0.20) M=21, (1.01±0.23) W=17, (1.05±0.16)	0.94 (0.45-1.46) N=52, (0.94±0.25) M=28, (0.91±0.25) W=24, (0.96±0.26)	0.90 (0.54-1.33) N=19, (0.97±0.25) M=8, (0.89±0.30) W=11, (0.99±0.20)	0.79 (0.46-1.60) N=20, (0.81±0.25) M=5, (0.77±0.12) W=15, (0.83±0.28)	(a vs b, c,d,e) (b vs e)	ns	(a vs c,e)	=0.04
	(a) Young adults (18-39 y.o.) N=29, M=13, W=16	(b) Adults (40-64 y.o.) N=40, M=21, W=19	(c) Older adults (65-89 y.o.) N=54, M=28, W=26	(d) Nonagenarians (90-99 y.o.) N=27, M=9, W=18	(e) Centenarians (100-111 y.o.) N=23, M=6, W=17	Age	Interaction		Gender
							M	W
Allele number (%)
FOXO3A rs2802292
G	25 (43%)	33 (41%)	41 (38%)	26 (48%)	17 (37%)	ns
T	33 (57%)	47 (59%)	67 (62%)	28 (52%)	29 (63%)
APOE rs439358, rs7412
ε2	5 (8%)	7 (9%)	7 (6%)	6 (11%)	6 (13%)	ns
ε3	49 (85%)	69 (86%)	93 (87%)	47 (87%)	39 (85%)
ε4	4 (7%)	4 (5%)	8 (7%)	1 (2%)	1 (2%)

Abbreviations: y.o.=years old; N=total number of cases; M=men; W=women; SD=standard deviation; RTL=relative telomere length; FOXO3A=Forkhead box O 3A; APOE= Apolipoprotein-E. Data underlined are the median (min-max) of the total number of cases. Data between round brackets are mean values±SD. a, b, c, d, and e indicate, respectively, young adults, adults, older adults, nonagenarians, and centenarians. The table shows the Pairwise comparisons between the different groups, i.e., a, b, c, d, and e stratified for gender. p-value≤0.05 is considered significant; ns=not significant.