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Natural compounds used to treat DN via targeting NLRP3 inflammasome. Orange dots refer to the therapeutic candidates. All the candidates exert inhibition effect on NLRP3 inflammasome. Red dots or molecules shown in red edged text box represent the down-regulated molecules besides NLRP3 inflammasome components by the specific drugs, while the blue ones represent the up-regulated molecules. ↑: promotional effect; ?: inhibitive effect.
