Figure 5.

Natural compounds in the treatment of diabetic retinopathy, diabetic encephalopathy, diabetes-associated NAFLD via targeting NLRP3 inflammasome. Orange dots refer to the therapeutic candidates. All the candidates exert inhibition effect on NLRP3 inflammasome. Red dots or molecules shown in red edged text box represent the down-regulated molecules besides NLRP3 inflammasome components by the specific drug, while the blue ones represent the up-regulated molecules. ↑: promotional effect; ⊥: inhibitive effect.