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. 2021 Sep 13;17(10):1075–1083. doi: 10.1038/s41589-021-00858-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 4 — a, Cryo-EM image processing flowchart for the complex containing ARIH2*, neddylated CRL5^Vif-CBFβ, and A3G. The portion of the reconstructions corresponding to A3G-Vif-CBFβ-ELOBC is visible only at low contour. This subcomplex is presumably mobile relative to the assembly between ARIH2* and neddylated CUL5-RBX2. Masks are shown in transparent yellow surface superimposed with grey maps. b, From top to bottom: two views showing local resolution colored on the A3G consensus map for the complex containing ARIH2*, neddylated CRL5^Vif-CBFβ, and A3G; Fourier Shell Correlation (FSC) curve showing the overall resolution of 3.8 Å with the FSC = 0.143 criterion; and angular orientation distribution of the final 3D reconstruction.