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. 2021 Sep 13;17(10):1075–1083. doi: 10.1038/s41589-021-00858-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 5 — a, Cryo-EM map of ARIH2* complex with neddylated CRL5^Vif-CBFβ-A3C, low-pass filtered to 7.5 Å resolution, and structures fit into the map^12,22,36,39. Crystal structure of ARIH2 (PDB ID: 7OD1) was determined in this study. b, Close-up of interface between ARIH2* Ariadne domain and RBX2, shown in A3C E3-E3catalytic DeepEMhancer map. c, Close-up of interface between ARIH2* Ariadne domain and CUL5, shown in A3C E3-E3catalytic DeepEMhancer map. d, Close-up of interface between ARIH2* N-terminal region and CUL5 groove, shown in A3C E3-E3catalytic DeepEMhancer map. e, Close-up of interface between NEDD8 and its linked CUL5 H29-helix shown in A3C E3-E3catalytic DeepEMhancer map. f, Close-up of 3-way junction between NEDD8 and its linked CUL5 WHB domain, and C/R domain portion of CUL5, shown in A3C E3-E3catalytic DeepEMhancer map. g, Domains from crystal structure of autoinhibited ARIH2 shown fit into A3C E3-E3catalytic focused map.