. 2021 Mar 19;28(11):6892–6905. doi: 10.1245/s10434-021-09774-6

Table 4.

Uni- and multivariate analysis of factors predictive for functional outcome in lower extremity STS patients

Characteristics	Univariate												Multivariate
Characteristics	TESS patients	TESS mean (SD)	β	p value	15D mob¹ patients	15D mob¹ mean (SD)	β	p value	PF² patients	PF² mean (SD)	β	p value	TESS β	p value	15D mob¹ β	p value	PF² β	p value
Eligible cases	141/141	86			135/141	83			135/141	75
		(17)				(19)				(24)
Age (years)³			− 0.3	< 0.01			− 0.4	< 0.01			− 0.6	< 0.01	− 0.3	< 0.01	− 0.4	< 0.01	− 0.6	< 0.01
18–40	10/10	98			09/10	97			9/10	96
		(4)				(10)				(9)
41–50	11/11	94			11/11	97			11/11	93
		(8)				(9)				(8)
51–60	19/19	86			18/19	80			19/19	74
		(18)				(15)				(25)
61–70	41/41	87			39/41	82			38/41	74
		(16)				(19)				(23)
71–80	38/38	87			37/38	84			36/38	79
		(13)				(17)				(17)
>80	22/22	75			21/22	73			22/22	55
		(25)				(20)				(29)
Obesity³			− 0.8	< 0.01			− 0.5	0.11			− 0.9	0.02	− 0.6	0.02	− 0.4	0.26	− 0.9	0.02
No obesity	41/41	89			40/41	83			41/41	78
		(14)				(19)				(24)
Overwight	45/45	89			45/45	87			44/45	78
		(16)				(18)				(22)
Obesity	37/37	80			37/37	77			37/37	67
		(17)				(19)				(24)
Tumor status			− 5.2	0.04			− 11.9	0.02	112/117		− 10.7	0.05	− 3.5	0.37	− 3.1	0.51	0.2	0.98
Primary	117/117	88			111/117	85				77
		(15)				(19)			23/24	(23)
Recurrence	24/24	78			24/24	76				66
		(23)				(18)				(26)
Reconstruction			− 7.7	0.02			− 8.1	0.03			− 9.3	0.05	− 6.7	0.04	− 6.3	0.1	− 10.4	0.03
None	106/106	88			101/106	85			100/106	78
		(16)				(19)				(22)
Reconstruction	35/35	81			34/35	77			35/35	68
		(19)				(18)				(26)
Motor nerve resection			− 10.7	0.03			− 13.5	0.01			− 15.2	0.03	− 7.4	0.12	− 8.9	0.12	− 9.5	0.17
No	127/127	87			122/127	84			122/127	77
		(15)				(18)				(22)
Yes	14/14	77			13/14	71			13/14	62
		(30)				(23)				(31)
Tumor depth			− 5.1	0.11			− 9.2	0.01			− 8.6	0.06	− 0.2	0.95	− 5.1	0.17	− 2.7	0.55
Superficial	40/40	90			40/40	90			39/40	81
		(17)				(17)				(23)
Deep	101/101	85			95/101	80			96/101	73
		(17)				(19)				(24)
Margins			6.3	0.01			4.6	0.08			6.7	0.05	0.7	0.8	− 0.5	0.87	1.8	0.64
Intralesional	11/11	81			11-Nov	82			11-Nov	68
		(17)				(18)				(23)
Marginal	76/76	84			73/76	80			74/76	73
		(19)				(19)				(26)
Wide	54/54	91			51/54	87			50/54	80
		(13)				(18)				(20)
Radiotherapy			− 8.5	< 0.01			− 6.3	0.05			− 5.8	0.16	− 7.5	0.01	− 4.9	0.17	− 4.5	0.3
No	83/83	90			80/83	86			78/83	78
		(14)				(18)				(21)
Yes	58/58	81			55/58	79			57/58	72
		(20)				(20)				(27)

Statistically significant univariate analysis results presented only (others reported in supplementary material)

p value < 0.05 were considered significant and are given in bold

PF physical function scale; QoL quality of life; SD standard deviation; β—unstandardized coefficients;DC direct closure

¹15D mobility item. In order to improve comparability with the other measures the 15D scale of 0–1 is converted into 0–100

²QLQ-C30 PF scale

³Tested as continuous variable

Overweight and obesity was defined as BMI ≥ 25 kg/m² and ≥ 30 kg/m², respectively

Location: proximal (groin, buttock, thigh) and distal (knee, lower leg, foot and ankle)

Variables analyzed in univariate analysis: age, BMI, gender, sarcoma type, tumor grade, tumor status, surgery, location, depth, motoric nerve resection, reconstruction surgery, tumor size, radiotherapy, complications, follow-up time. Statistically insignificant results are presented as supplementary material