. 2021 Mar 19;28(11):6892–6905. doi: 10.1245/s10434-021-09774-6

Table 6.

Uni- and multivariate analysis of factors predictive for HRQoL in lower extremity STS patients

Characteristics	Univariate								Multivariate
Characteristics	15D patients	15D¹ mean (SD)	β	p value	QLQ-C30 patients	QoL²mean (SD)	β	p Value	15D¹ β	p value	QoL² β	p value
Eligible cases	135/141	88			137/141	73
		(11)				(22)
Age (years)³			− 0.2	< 0.01			− 0.4	< 0.01	− 0.2	< 0.01	− 0.3	< 0.01
18–40	9/10	96			9/10	88
		(6)				(10)
41–50	11/11	94			11/10	82
		(6)				(15)
51–60	18/19	87			19/19	71
		(15)				(24)
61–70	39/41	87			39/41	74
		(11)				(22)
71–80	37/38	90			37/38	76
		(9)				(17)
>80	21/22	81			22/22	57
		(13)				(25)
Obesity³			− 0.5	0.01			− 0.7	0.04	− 0.5	< 0.01	− 0.7	0.05
No obesity	40/41	90			41/41	76
		(10)				(18)
Overwight	45/45	89			45/45	77
		(10)				(20)
Obesity	37/37	84			37/37	67
		(12)				(24)
Tumor status			− 5.2	0.04			− 11.9	0.02	0.1	0.96	− 3.7	0.45
Primary	111/117	89			113/117	75
		(11)				(21)
Recurrence	24/24	84			23/24	63
		(12)				(25)
Reconstruction			− 3.4	0.14			− 9.5	0.03	− 3.7	0.09	− 11.1	< 0.01
None	101/106	89			102/106	75
		(11)				(21)
Reconstruction	34/35	85			35/35	66
		(12)				(24)

Statistically significant univariate analysis results presented only (others reported in supplementary material)

p value < 0.05 were considered significant and are given in bold

PF physical function factor; QoL quality of life; SD standard deviation; β unstandardized coefficients

¹15D overall score. In order to improve comparability with the other measures the 15D scale of 0–1 is converted into 0–100

²QLQ-C30 QoL scale

³Tested as continuous variable

Overweight and obesity was defined as BMI ≥ 25 kg/m² and ≥ 30 kg/m², respectively

Variables analyzed in univariate analysis: age, BMI, gender, sarcoma type, tumor grade, tumor status, surgery, location, depth, motoric nerve resection, reconstruction surgery, tumor size, radiotherapy, complications, follow-up time