Table 2.
Cutoff determination for PLR, NLR, and LMR using maximally selected rank statistics
| Marker | 1-Year overall survival | 1-Year recurrence free survival | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Cutoff | HR | 95% CI | p value | Cutoff | HR | 95% CI | p value | ||||
| PLR | Preop | 245.93 |
Below: 131 Above: 30 |
2.896 | 1.697–4.943 | < 0.001 | 111.73 |
Below: 36 Above: 125 |
1.447 | 0.932–2.245 | 0.100 |
| Postop < 24 h | 512.90 |
Below: 128 Above: 26 |
2.702 | 1.523–4.792 | 0.001 | 155.56 |
Below: 21 Above: 133 |
0.637 | 0.388–1.047 | 0.075 | |
| Post-op days 1–3 | 255.40 |
Below: 103 Above: 53 |
2.250 | 1.412–3.586 | 0.001 | 389.17 |
Below: 137 Above: 19 |
1.436 | 0.816–2.527 | 0.209 | |
| Postop days 4–7 | 288.15 |
Below: 92 Above: 49 |
3.081 | 1.891–5.021 | < 0.001 | 285.37 |
Below: 90 Above: 51 |
1.576 | 1.051–2.363 | 0.028 | |
| Postop days 8–21 | 546.36 |
Below: 77 Above: 33 |
2.341 | 1.374–3.990 | 0.002 | 251.83 |
Below: 19 Above: 91 |
1.568 | 0.879–2.798 | 0.128 | |
| Postop days 22–56 | 369.65 |
Below: 92 Above: 20 |
5.629 | 3.087–10.264 | < 0.001 | 200.44 |
Below: 57 Above: 55 |
1.751 | 1.131–2.711 | 0.012 | |
| Postop days 57–90 | 141.79 |
Below: 31 Above: 67 |
4.788 | 2.021–11.341 | < 0.001 | 101.80 |
Below: 16 Above: 82 |
7.127 | 2.525–20.116 | <0.001 | |
| NLR | Preop | 2.99 |
Below: 108 Above: 53 |
1.553 | 0.973–2.480 | 0.065 | 1.41 |
Below: 15 Above: 146 |
1.449 | 0.750–2.797 | 0.270 |
| Postop < 24 h | 6.33 |
Below: 22 Above: 132 |
0.304 | 0.175–0.526 | <0.001 | 7.20 |
Below: 27 Above: 127 |
0.453 | 0.282–0.728 | 0.001 | |
| Postop days 1–3 | 18.71 |
Below: 135 Above: 21 |
2.401 | 1.405–4.104 | 0.001 | 14.83 |
Below: 118 Above: 38 |
0.711 | 0.461–1.096 | 0.122 | |
| Postop days 4–7 | 7.99 |
Below: 89 Above: 52 |
3.298 | 2.022–5.379 | <0.001 | 7.73 |
Below: 84 Above: 57 |
1.785 | 1.202–2.652 | 0.004 | |
| Postop days 8–21 | 13.26 |
Below: 96 Above: 14 |
3.638 | 1.894–6.988 | <0.001 | 5.83 |
Below: 50 Above: 60 |
1.601 | 1.030–2.490 | 0.037 | |
| Postop days 22–56 | 2.76 |
Below: 53 Above: 59 |
2.732 | 1.489–5.015 | 0.001 | 2.76 |
Below: 53 Above: 59 |
1.864 | 1.188–2.925 | 0.007 | |
| Postop days 57–90 | 3.48 |
Below: 74 Above: 24 |
2.618 | 1.465–4.679 | 0.001 | 1.57 |
Below: 28 Above: 70 |
2.416 | 1.360–4.289 | 0.003 | |
| LMR | Preop | 2.86 |
Below: 63 Above: 98 |
0.502 | 0.312–0.807 | 0.004 | 4.59 |
Below: 130 Above: 31 |
0.794 | 0.506–1.245 | 0.315 |
| Postop < 24 h | 2.32 |
Below: 130 Above: 24 |
2.403 | 1.419–4.070 | 0.001 | 2.87 |
Below: 137 Above: 17 |
1.419 | 0.806–2.498 | 0.226 | |
| Postop days 1–3 | 3.03 |
Below: 138 Above: 18 |
0.485 | 0.217–1.080 | 0.076 | 2.68 |
Below: 133 Above: 23 |
0.514 | 0.290–0.909 | 0.022 | |
| Postop days 4–7 | 0.93 |
Below: 14 Above: 127 |
0.172 | 0.091–0.325 | <0.001 | 3.09 |
Below: 126 Above: 15 |
0.312 | 0.143–0.680 | 0.003 | |
| Postop days 8–21 | 0.91 |
Below: 14 Above: 96 |
0.327 | 0.162–0.659 | 0.002 | 2.88 |
Below: 97 Above: 13 |
0.264 | 0.105–0.663 | 0.005 | |
| Postop days 22–56 | 1.93 |
Below: 30 Above: 82 |
0.348 | 0.201–0.602 | <0.001 | 2.37 |
Below: 43 Above: 69 |
0.544 | 0.347–0.851 | 0.008 | |
| Postop days 57–90 | 1.78 |
Below: 19 Above: 79 |
0.503 | 0.266–0.950 | 0.034 | 1.56 |
Below: 11 Above: 87 |
0.349 | 0.162–0.751 | 0.007 | |
Values in bold indicate p > 0.05
HR hazard ratio, CI confidence interval, Preop preoperative, Postop, postoperative, PLR platelet–lymphotycte ratio, NLR neutrophil–lymphocyte ratio, LMR lymphocyte–monocyte ratio