Figure 3.
A. Representative tracing of 5-HT-induced contraction in isolated rat Ab VC exposed to vehicle (black) or 5-HT7 receptor antagonist DR 4485 (gray; 50 nM). B. Concentration-dependent contraction stimulate by 5-HT in the absence (vehicle) and presence of the 5-HT7 receptor antagonist DR 4485 (50 nM) in Ab VC isolated from the male Sprague Dawley rat. Points represent means±SEM for the number of biological replicates reported as N. * signifies statistically significant differences (p<0.05, unpaired t test) between maximum responses of vehicle- and DR 4485-incubated tissues.