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. Author manuscript; available in PMC: 2022 Sep 1.
Published in final edited form as: Mol Microbiol. 2021 Jul 4;116(3):827–840. doi: 10.1111/mmi.14773

Figure 7. Model of the role of DRBD18 in mRNA export.

Figure 7.

A model summarizing the potential role of DRBD18 in mRNA export from nucleus to cytosol through the Nuclear Pore Complex (NPC; see text for details). Inset shows the detailed architecture of NPC and its structural components (Nups). Core scaffold Nups, dark grey (outer ring) and light grey (inner ring); FG Nups, green; nuclear basket, black; cytosolic filament, blue. The NPC has left to right symmetry, and specific features are labeled on only one side for clarity, although they are present on both sides. DRBD18, orange; Mtr2, yellow; Mex67, olive green. DRBD18 may promote association of select mRNAs with Mex67/Mtr2 and likely acts as a chaperone that facilitates passage of the Mex67/Mtr2-DRBD18 mRNP across the NPC due to its interactions with the outer ring and Nup76 complex.