Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Sep 23;4:1124. doi: 10.1038/s42003-021-02624-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Crown 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 7 — a Heatmap of interactions reflects binding indexes, distributed from the highest (BI = 1) to the lowest (BI = 0), based on Association Quotients (Q) from TCCD data and maximum luminescence using AlphaScreen proximity assay. Each colour depicts the average of triplicate measurements of one pairwise interaction with a LB component. Proteins are organized broadly, based on biological process. Previously identified PPIs (as described in BIOGRID) and genetically relevant proteins are highlighted. b Binding indexes allowed for representation of individual interactomes for each species of α-SYN tested (M—monomer, O—G51D/A53T cell-free aggregated species and F—amyloid fibrils). Proteins are grouped by biological process and distance to the centre represents magnitude of binding index.