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. 2021 Sep 23;12:5617. doi: 10.1038/s41467-021-25928-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Detailed information about the linkers that were used and the structures of the hyPE2 linker variants. DBD DNA-binding domain, NLS nuclear-localization signal, RT reverse transcriptase. b Prime-editing efficiencies of hyPE2 variants normalized to the efficiency of hyPE2 at the same target sequences, which had been lentivirally integrated in HEK293T cells. Adjusted fold increases are shown on the y axis. Data of minimum-to-maximum values are presented. For the boxes, the top, middle, and bottom lines represent the 25th, 50th, and 75th percentiles, respectively. The whiskers indicate the 10th- and 90th-percentile values. The number of pegRNAs n = 82. Source data are provided as a Source Data file.