Table 2.
Baseline demographics and clinical features of the overall hospitalized study population for SARS-CoV-2 related infection, and of the two subgroups categorized in low (LIMC) and high (HIMC) intensity medical care.
|
Overall Hospitalized Study Population
(n = 127) |
Low-intensity medical care (LIMC)
(n = 51) |
High-intensity medical care (HIMC)
(n = 76) |
p-value | |
|---|---|---|---|---|
| Male—n (%) | 82 (65) | 28 (55) | 54 (71) | 0.06 |
| Age at admission—years | 72 (58–81) | 64 (52–75) | 77 (63–82) | 0.001 |
| Smoking history—pack years | 0 (0–16) | 0 (0–10) | 0 (0–25) | 0.29 |
| Current—n (%) | 6 (5) | 3 (6) | 3 (4) | 0.61 |
| Former—n (%) | 54 (42) | 19 (37) | 35 (46) | 0.32 |
| Non-smokers—n (%) | 67 (53) | 29 (57) | 38 (50) | 0.52 |
| BMI—kg/m2 | 27.1 (23.5–30.5) | 26.1 (21.2–29.2) | 30 (25–31) | 0.003 |
| Comorbidities—n (%) | ||||
| Cardiovascular diseases (CVD) | 81 (64) | 23 (45) | 58 (76) | <0.0001 |
| Chronic respiratory diseases | 23 (18) | 5 (10) | 18 (24) | 0.04 |
| Autoimmune diseases | 15 (12) | 6 (12) | 9 (12) | 0.99 |
| Metabolic diseases | 54 (43) | 14 (27) | 40 (53) | 0.0003 |
| Oncologic diseases | 20 (16) | 8 (16) | 12 (16) | 0.98 |
| Viral load (Gene E)—log10 copies/ml | 4.68 (3.8–5.9) | 4.8 (3.6–6.1) | 4.6 (3.9–5.7) | 0.96 |
| Lag time symptoms–diagnosis—days | 5 (1–7) | 4 (0–7) | 5 (2–7) | 0.20 |
| P/F at admission—ratio | 225 (108–429) | 429 (364–429) | 125 (66–191) | <0.0001 |
| CARE score at admission | 7 (2–15) | 3 (1–5) | 13 (5–20) | <0.0001 |
| Hospitalization—days | 13 (5–24) | 7 (3–13) | 18 (8–29) | <0.0001 |
| Bacterial co-infections—n (%) | 40 (32) | 7 (14) | 33 (34) | <0.0001 |
| Dead—n (%) | 26 (20) | 0 (0) | 26 (34) | <0.0001 |
Values are expressed as numbers and (%) or median and interquartile range, as appropriate. To compare demographic between LIMC and HIMC, Chi square test, and Fisher t-test (n <5) for categorical variables and Mann-Whitney t-test for continuous variables were used, as appropriate. Bold values are significant p-values.