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. 2021 Sep 10;8:720019. doi: 10.3389/fmed.2021.720019

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Copyright © 2021 Lu, Wang, Sun, Zhang, Yan, Wang, Gao, Yin, Wang, Li and Hou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Quality assessment. (A) Risk of bias graph; (B) risk of bias summary. The overall risk of bias in randomized controlled trials (RCTs) was rated as moderate to high for issues related to blinding. Owing to the type of intervention, patients and health care research team could not be blinded for group assignment, as it was responsible for the personalized and technical support of the TM tool. In addition, most studies had reasonable random sequence generation. However, only six studies specified whether data collectors and outcome assessors were masked to treatment allocation.