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. 2021 Sep 23;11:18874. doi: 10.1038/s41598-021-98053-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Shown are the changes in median pathway expression (gene set) between ARDS survivors and non-survivors for specifically identified pathways including HDAC (A), TGFβ (B), IL-6 (C), Chromatin (D), sumoylation (E), and TP53 (F). Each line represents the gene expression of a pathway gene. The color of the line represented the cluster of the pattern, a line within the same group with the same color means the patterns of change for those genes are similar. For example, in the TGF-β signaling pathway, the gene expression change was homogeneous in the survivor group (all blue) while two clusters of patterns existed in the non-survivor group (blue and red). The adjusted p-value represented the significance of those patterns changes between groups. The color reflects the pattern of the gene expression change within that specific pathway and group (not use to compare groups or pathways). The red only lines in the HDAC pathway indicate non-survivor and survivor gene pattern change have only one pattern whereas in the TGFβ pathway non-survivors have two patterns (red and blue) but survivors only one pattern.