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. 2021 Sep 23;11:18874. doi: 10.1038/s41598-021-98053-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(A) AUC plots of the prediction model using Day 7 Ang2 and IL1R2 (alone and combined). Day 7 Ang2 alone has significant discrimination between ARDS survivor/non-survivor groups. (B) Mean concentration of Ang2 in Day 0 (baseline) and Day 7 between ARDS survivor/non-survivor groups showed the mean concentration of Ang2 decrease with time in the survivor group. * Mean concentration for death; ** Mean concentration for survivors. (C) Independent variable optimized cutoff and distribution by class (0 = alive, 1 = death); cutoff concentration of 12.1 ng/mL. (D) ROC curve, sensitivity and specificity using Day 7 Ang2 protein level to predict ARDS mortality which showed with the cutoff concentration of 12.1 ng/mL, the specificity for ARDS mortality is high at 0.89.