Table 4.

Significant pathways associated with ARDS mortality using the Overlap gene approach.

Pathway name	set size	# Candidatesa	q-value	Source
RNA polymerase II transcription	1236	4 (0.3%)	0.00598	Reactome
Gene expression (transcription)	1373	4 (0.3%)	0.00598	Reactome
Regulation of TP53 activity	162	2 (1.2%)	0.00598	Reactome
PIP3 activates AKT signaling	214	2 (0.9%)	0.00775	Reactome
Intracellular signaling by second messengers	245	2 (0.8%)	0.00808	Reactome
Generic transcription pathway	1107	3 (0.3%)	0.0129	Reactome
Transcriptional regulation by TP53	374	2 (0.5%)	0.0129	Reactome

^aNumbers of genes in the pathway are from the 10 genes identified through the Overlap gene approach.