Table 1.

In-silico ADME evaluation of synthesized compounds (3a-u).

Compound	TPSAa	LVb	PAINSc	WLOGPd	AHAe	BBBf	GIAg	LLh	BAi
3a	92.69	0	0	3.92	18	No	High	0	0.55
3b	112.92	0	0	3.62	18	No	High	1	0.55
3c	112.92	0	0	4.39	18	No	High	1	0.55
3d	122.15	0	0	3.63	18	No	High	1	0.55
3e	138.51	0	0	3.83	18	No	Low	1	0.55
3f	95.93	0	0	3.98	18	No	High	1	0.55
3g	92.69	0	0	4.48	18	No	High	1	0.55
3h	101.92	0	0	3.93	18	No	High	1	0.55
3i	112.92	0	0	4.28	18	No	High	1	0.55
3j	112.92	0	0	4.18	18	No	High	1	0.55
3k	133.15	0	0	3.33	18	No	Low	1	0.55
3l	92.69	0	0	5.24	18	No	High	1	0.55
3m	92.69	0	0	5.13	18	No	High	1	0.55
3n	92.69	0	0	5.24	18	No	High	1	0.55
3o	92.69	0	0	5.33	18	No	High	2	0.55
3p	92.69	0	0	5.13	18	No	High	1	0.55
3q	92.69	0	0	5.22	18	No	High	2	0.55
3r	92.69	0	0	5.04	18	No	High	1	0.55
3s	92.69	0	0	5.44	18	No	High	2	0.55
3t	112.92	0	0	3.62	18	No	High	1	0.55
3u	112.92	0	0	3.93	18	No	High	1	0.55

^aTopological polar surface area, ^bLipinski violations, ^cpan-assay interference, ^dlogarithm of partition coefficient between n-octanol and water, ^earomatic heavy atom, ^fblood brain barrier permeation, ^ggastrointestinal absorption, ^hlead likeness, ⁱbioavailability.