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. 2021 Sep 23;11:18964. doi: 10.1038/s41598-021-98640-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Least square regression model of perceptual speed. (A) Actual by predicted plot of a whole model and leverage plots of model components. (B) Model cross-validation statistics using training set (60%, n = 44) and validation set (40%, n = 33). (C) Model components of soluble epoxide hydrolase metabolism projected onto their metabolic pathway. Metabolic pathway starts with the fatty acids on the left, farther, metabolizing enzymes are indicated on the arrows. Multiple possible metabolites of the pathway are indicated. Metabolites of sEH used for the model are highlighted. Color of the metabolites as well as an arrow next to the metabolic pathway represents directionality of the correlation with perceptual speed (orange—positive, blue—negative). RMSE root mean squared error, LA linoleic acid, CYP 450 cytochrome p450, sEH soluble epoxide hydrolase, EpOME epoxy octadecanoic acid, DiHOME dihydroxy octadecanoic acid, EpETE epoxy eicosatrienoic acid, DiHETE dihydroxy eicosatrienoic acid, EpDPE epoxy docosapentaenoic acid, DiHDoPE dihydroxy docosapentaenoic acid.