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. 2021 Sep 23;11:18936. doi: 10.1038/s41598-021-98410-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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SWATH-MS analysis of PCa. (A) non-supervised hierarchical clustering of top 500 most variant proteins. Sample types were annotated by colors beyond the heat map as: NAG (blue), AG (red), Nmet (brown), M (black) and C (green). Protein clusters were labelled by colors on the left side of the heat map as: cluster 1 (green), cluster 2 (orange), cluster 3 (blue), and cluster 4 (red). (B) PCA analysis. (C) Volcano plot of significantly expressed proteins in tumors (NAG, AG, Nmet, and M groups) and controls C. (D) Gene set enrichment analysis (GSEA) of differentially expressed proteins based on biological process terms in the gene ontology database accessed via WebGestalt.