FIGURE 1.

Obesogenic diets did not impair the anticontractile effect of mesenteric PVAT in male mice. Concentration-response curves to phenylephrine in mesenteric arteries without PVAT (PVAT-; white symbols) or in the presence of adjacent PVAT (PVAT +; blue filled symbols) of male mice fed a chow diet (CD; A,E; circle symbols), high-fat diet (HF; B,F; triangle symbols) or HF plus high-sucrose diet (HF + HS; C,G; square symbols) for 3 (left panel) or 5 (right panel) months. Bar graphs show the potency of the response to phenylephrine (pEC₅₀) (D,H) in PVAT- (white bars) and PVAT+ (blue filled bars) arteries. The experimental number used is in parenthesis. **p < 0.01; ***p < 0.001 vs. PVAT- arteries (Mann–Whitney U test).