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. 2021 Sep 10;12:720224. doi: 10.3389/fphar.2021.720224

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Copyright © 2021 Victorio, Guizoni, Freitas, Araujo and Davel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The anticontractile effect of mesenteric PVAT is reduced by high-fat and high-fat plus high-sucrose diets in female mice. Concentration-response curves to phenylephrine in mesenteric arteries without PVAT (PVAT-; white symbols) or in the presence of adjacent PVAT (PVAT +; pink filled symbols) from female mice fed a chow diet (CD; A,E; circle symbols), high-fat diet (HF; B,F; triangle symbols), or HF plus high-sucrose diet (HF + HS; C,G; square symbols) for 3 (left panel) or 5 (right panel) months. Bar graphs show the potency of the response to phenylephrine (pEC₅₀) (D,H) in PVAT- (white bars) and PVAT+ (pink filled bars) arteries. The experimental number used is in parenthesis. ****p < 0.0001 vs. PVAT- (pEC₅₀ 3 months) (Mann–Whitney U test). *p < 0.05, ****p < 0.0001 vs. PVAT- (pEC₅₀ 5 months) (two-way ANOVA).