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. 2021 Sep 10;12:720224. doi: 10.3389/fphar.2021.720224

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Copyright © 2021 Victorio, Guizoni, Freitas, Araujo and Davel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of adjacent PVAT on acetylcholine-induced relaxation of mesenteric arteries from female mice. Concentration-response curves to acetylcholine in mesenteric arteries without PVAT (PVAT-; white symbols) or in the presence of adjacent PVAT (PVAT +; pink filled symbols) from female mice fed a chow diet (CD; A,D; circle symbols), high-fat diet (HF; B,E; triangle symbols), and HF plus high-sucrose diet (HF + HS; C,F; square symbols) for 3 (left panel) or 5 (right panel) months. Bar graphs show the potency of the response to acetylcholine (pEC₅₀) (D,H) in PVAT- (white bars) and PVAT+ (pink filled bars). The experimental number used is in parenthesis. p > 0.05 (two-way ANOVA).