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. 2021 Sep 10;12:729568. doi: 10.3389/fphar.2021.729568

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Copyright © 2021 Jarkovská, Miklovič, Švíglerová, Červenka, Škaroupková, Melenovský and Štengl.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Isolated cardiac tissue. (A) Effect of norepinephrine on spontaneous activity of isolated atria from sham-operated rats (n = 12), ACF rats (n = 10) and ACF rats with trandolapril (n = 10). (B) Contraction force in left ventricle trabeculae of sham-operated rats (n = 12), ACF rats (n = 10) and ACF rats with trandolapril (n = 10). (C) Action potential duration at 75% repolarization (APD₇₅) in left ventricle trabeculae of sham-operated rats (n = 12), ACF rats (n = 10) and ACF rats with trandolapril (n = 10). (D) Representative cellular action potentials in left ventricle trabeculae of a sham-operated rat, an ACF rat, and an ACF rat with trandolapril at stimulation frequency of 1 Hz. *p < 0.05.