Fig. 3.

Deletion of neuronal DLK decreases edema and hemorrhage caused by CYP. Bladder tissues from WT and cKO mice were harvested after cystitis induction (a−d). a The representative HE images of bladder morphology. The wet weight of empty bladder (b), macroscopic edema (c), and hemorrhage (d) were evaluated. n = 6. Significance was evaluated between WT and cKO groups in the same conditions. **p < 0.01 and ***p < 0.001. Error bars represent SEM. ns, not significant; DLK, dual leucine zipper kinase; CYP, cyclophosphamide.