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. 2021 Sep 10;12:713351. doi: 10.3389/fimmu.2021.713351

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Copyright © 2021 Körber, Pohl, Weinberger, Grubeck-Loebenstein, Wawer, Knolle, Roggendorf, Protzer and Bauer

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of frequencies of CD19⁺IL-10⁺ B (B10⁺) cells of second-generation hepatitis B vaccine non-responders and responders. Depicted are frequencies of B10⁺ cells of second-generation hepatitis B vaccine non-responders (NR, red circles) and second-generation hepatitis B vaccine responders (R, blue circles) before (day 0) and 7, and 28 days after vaccination with a third- (NR group) or second- (R group) generation hepatitis B vaccine, respectively. The boxes show the median and the 25^th and 75^th percentile. Whiskers indicate the highest and lowest values. Statistical analyses are based either on unpaired Mann-Whitney U tests for the analysis of the NR vs. the R group or on Friedman tests with post Wilcoxon signed rank testing for analysis of the impact of third- and second-generation hepatitis B vaccines within the NR or R group. ***p < 0.001; ****p < 0.0001.