Figure 5.

Frequencies of CD24⁺CD27⁺ (A), CD24^highCD38^high (B), CD24⁺CD27⁺IL-10⁺ (C), CD24^highCD38^highIL-10⁺ Breg (D), and CD19⁺IL-10⁺ B (B10⁺) cells (E) of third-generation hepatitis B vaccine low- and high-responders. Depicted are (CpG+P/I)-induced frequencies of CD24⁺CD27⁺ (A), CD24^highCD38^high (B), CD24⁺CD27⁺IL-10⁺ (C), CD24^highCD38^highIL-10⁺ Breg (D) and CD19⁺IL-10⁺ B (B10⁺) cells (E) of third-generation hepatitis B vaccine low- (LR) and high-responders (HR) (red circles, n = 5, respectively) before (day 0) and 7, and 28 days after vaccination with a third-generation hepatitis B vaccine. The boxes show the median and the 25^th and 75^th percentile. Whiskers indicate the highest and lowest values. Statistical analyses are based on unpaired Mann-Whitney U tests. *p < 0.05.