Table 2.
Frequencies and cytokine expression levels of CD24+CD27+ and CD24highCD38high Breg and B10+ cells.
| Cell population | Time point | 2nd HBvac NR; Median (min-max) (%) | 2nd HBvac R; Median (min-max) (%) | p-value |
|---|---|---|---|---|
| CD24+CD27+ Breg | d0 | 10.70 (3.33 – 24.3) | 3.07 (1.44 – 15.50) | 0.062 |
| d7 | 10.30 (2.62– 19.40) | 3.75 (1.52 – 16.80) | 0.059 | |
| d28 | 8.62 (2.47 – 17.90) | 4.56 (1.75 – 13.30) | 0.109 | |
| CD24highCD38high Breg | d0 | 5.67 (3.84 – 14.10) | 3.04 (1.63 – 4.63) | 0.004 |
| d7 | 5.42 (2.54 – 12.20) | 3.22 (1.88 – 6.48) | 0.051 | |
| d28 | 5.20 (2.59 – 12.50) | 2.84 (1.23 – 4.75) | 0.012 | |
| CD24+CD27+IL-10+ Breg | d0 | 1.63 (1.08 – 3.63) | 7.92 (5.14 – 15.90) | <0.0001 |
| d7 | 1.84 (1.04 – 5.31) | 11.0 (2.95 – 15.0) | 0.0004 | |
| d28 | 2.19 (1.20 – 6.08) | 9.61 (5.10 – 19.40) | 0.0003 | |
| CD24highCD38highIL-10+ Breg | d0 | 0.89 (0.39 – 1.75) | 3.85 (2.73 – 5.75) | 0.016 |
| d7 | 1.59 (0.36 – 1.79) | 2.48 (2.11 – 3.97) | 0.016 | |
| d28 | 1.39 (0.58 – 1.93) | 2.68 (1.03 – 4.80) | 0.111 | |
| CD24+CD27+IL-35+ Breg | d0 | 1.68 (0.48 – 2.14) | 1.19 (0.76 – 2.54) | ND |
| d7 | 1.39 (0.73 – 3.06) | 1.05 (0.71 – 2.73) | ND | |
| d28 | 1.23 (0.52 – 3.94) | 1.76 (0.70 – 2.34) | ND | |
| CD24+CD27+TGF-ß+ Breg | d0 | 1.49 (0.78 – 3.20) | 0.31 | ND |
| d7 | 1.34 (0.89 – 2.09) | 0.66 | ND | |
| d28 | 1.31 (0.79 – 3.21) | 0.38 | ND | |
| CD24highCD38highTGF-ß+ Breg | d0 | 1.44 (0.77 – 1.85) | U | ND |
| d7 | 1.07 (0.72 – 2.20) | U | ND | |
| d28 | 1.18 (0.60 - 2.44) | U | ND | |
| B10+ cells | d0 | 0.70 (0.28 – 1.51) | 2.24 (1.29 – 4.40) | <0.0001 |
| d7 | 0.66 (0.23 – 2.01) | 2.13 (1.53 – 3.67) | 0.0005 | |
| d28 | 0.77 (0.24 – 1.75) | 2.18 (1.21 – 3.92) | 0.0001 |
U, undetectable; ND, not done.