Table 3.
Frequencies and cytokine expression levels of CD24+CD27+ and CD24highCD38high Breg and B10+ cells of 3rd HBvac LR and 3rd HBvac HR.
| Cell population | Time point | 3rd HBvac LR; Median (min-max) (%) | 3rd HBvac HR; Median (min-max) (%) | p-value |
|---|---|---|---|---|
| CD24+CD27+ Breg | d0 | 14.0 (10.60 – 24.30) | 7.86 (3.33 – 11.60) | 0.032 |
| d7 | 11.50 (10.30 – 19.40) | 8.22 (2.62 – 10.70) | 0.024 | |
| d28 | 10.60 (6.72 – 17.90) | 7.92 (2.47 – 12.80) | 0.548 | |
| CD24highCD38high Breg | d0 | 4.20 (2.90 – 5.42) | 6.50 (3.81 – 10.90) | 0.095 |
| d7 | 3.51 (2.57 – 5.09) | 7.56 (2.61 – 10.30) | 0.095 | |
| d28 | 3.60 (2.46 – 3.93) | 7.98 (2.66 – 12.0) | 0.095 | |
| CD24+CD27+IL-10+ Breg | d0 | 3.09 (1.08 – 3.63) | 1.63 (1.27 – 2.73) | 0.548 |
| d7 | 3.02 (1.66 – 5.31) | 1.63 (1.04 – 2.93) | 0.056 | |
| d28 | 2.42 (1.51 – 6.08) | 2.19 (1.20 – 4.22) | 0.999 | |
| CD24highCD38highIL-10+ Breg | d0 | 0.89 (0.73 – 1.29) | 1.07 (0.39 – 1.75) | ND |
| d7 | 1.59 (1.05 – 1.79) | 1.07 (0.36 – 1.77) | ND | |
| d28 | 1.39 (0.99 – 1.42) | 1.26 (0.58 – 1.93) | ND | |
| B10+ cells | d0 | 1.15 (0.41 – 1.51) | 0.65 (0.48 – 0.83) | 0.310 |
| d7 | 1.20 (0.61 – 2.01) | 0.63 (0.36 – 0.91) | 0.056 | |
| d28 | 1.04 (0.60 – 1.75) | 0.77 (0.65 – 1.12) | 0.595 |
ND, not done.