Table 3.
Clusters of COVID-19 patients according to complement parameters.
| RI | Cluster 1 | Cluster 2 | Cluster 3 | Cluster 4 | p-value | p-value comparison 2 by 2 | |
|---|---|---|---|---|---|---|---|
| Number | 20 | 19 | 20 | 15 | |||
| TH50c % mean (sd) | 86–126 | 128.1 (27.1) | 145.2 (27.3) | 117.5 (22.7) | 100.6 (24.8) | <0.00011 | p = 0.001 cluster 4 against others; p < 0.0001 cluster 2 against others |
| TH50a % median (IQR) | 84–150 | 132 (80;189) | 99 (75;147) | 122 (95;171) | 62 (43;77) | 0.0032 | p = 0.0004 cluster 4 against others |
| C1q mg/L mean (sd) | 154–258 | 201.4 (40.1) | 234.3 (32.5) | 215.9 (52.2) | 175.2 (52.4) | 0.0031 | p = 0.003 cluster 4 against others: p = 0.006 cluster 2 against others |
| C4 mg/L mean (sd) | 100–380 | 367.8 (77.8) | 374.7 (112.9) | 317.1 (79.5) | 182.3 (85.1) | <0.00011 | p < 0.0001 cluster 4 against others |
| C3 mg/L mean (sd) | 880–1650 | 1440 (66.7) | 1795.3 (189.8) | 1149.5 (99.0) | 878.1 (149.9) | <0.00011 | p < 0.0001cluster 2 against others; cluster 4 against others |
| Factor B mg/L mean (sd) | 216–504 | 473.5 (134.0) | 585.6 (122.6) | 436.9 (110.5) | 345 (134.8) | <0.00011 | p < 0.0001 cluster 2 against others; cluster 4 against others |
| C5 mg/L median (IQR) | 120–220 | 216 (202;249) | 278 (261;331) | 199 (177;230) | 174 (155;201) | <0.00012 | p < 0.0001 cluster 2 against others; p = 0.0001 cluster 4 against others |
| MBL antigen µg/L median (IQR) | 30–3000 | 900 (318;3200) | 1025 (625;1750) | 725 (171;1375) | 270 (42;1500) | 0.03742 | p = 0.0170 cluster 4 against others |
| MBL function* % median (IQR) | 35–115 | 110 (24;187) | 117 (62;200) | 43 (28;181) | 13 (0;168) | 0.05582 | |
| C4 hemolytic activity* % mean (sd) | 70–130 | 125 (8.1) | 117.3 (50.8) | 104.1 (40.8) | 66.6 (49.0) | 0.0041 | p = 0.001 cluster 4 against others |
Mean (sd) or median (IQR) were presented for the parametric or non-parametric variables, respectively. RI, reference interval.
*Post-hoc analysis was performed for this parameter. 1 Fisher ANOVA test. 2 Kruskal-Wallis test.