TABLE 1.

The main physiological functions of Mfsd2a in nervous system.

First author, year	Function	Mechanism	Species
Ben-Zvi et al., 2014	To act as an essential regulator of BBB function	It might work via inhibiting cell transport in CNS endothelial cells	Mice
Andreone et al., 2017	To maintain and regulate the integrity and permeability of BBB	Specifically inhibits vesicle mediated transcytosis in BBB capillary endothelial cells	Mice
Yang et al., 2017	To avoid BBB injury in cerebral hemorrhage model	Mfsd2a overexpresses in perihematomas	Mice
Qu et al., 2020	To promotes brain development and the formation of cognitive abilities	Mfsd2a could alleviate BBB injury and improve cognitive function in CCH rats	Rats
Quek et al., 2016	To act as a carrier, transporting DHA into the brain	Lys-436 was identified as a key residue for transport	Mice

BBB, blood-brain barrier; DHA, docosahexaenoic acid; CNS, central nervous system; CCH, chronic cerebral hypoperfusion.