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. 2021 Sep 10;12:734463. doi: 10.3389/fphys.2021.734463

TABLE 2.

A summary of the results of the lab tests on the toxicities of contaminant mixtures with other pollutants in addition to PAHs is organized here.

Species Contaminant Biomarker Effect References
C. virginica WAF of PAHs in sediment Infection Increased prevalence of Perkinsus infection Chu and Hale. 1994
C. virginica PAHs + heavy metals + pesticides in sediment suspension Histology Extensive neoplasia Renal cell tumors, Gill filament tumors, Gastrointestinal adenocarcinoma Neuroblastoma, Circulatory system tumors, Gonadal papillary lesions Gardner et al., 1991
M. gigas PAHs + heavy metals + miscellaneous contaminants in sediment or elutriate Gamete health Fertilization Embryogenesis No change in fertilization rate, Larval abnormalities Geffard et al., 2001
M. gigas PAH Heavy metals PAHs + heavy metals miscellaneous contaminants elutriate, contaminated algae Embryogenesis Larval growth Larval abnormalities, Mortality, Delayed larval growth Geffard et al., 2002
M. gigas PAHs + heavy metals (Cd, Cu, Zn) + miscellaneous contaminants in sediment or elutriate Larval growth Metallothionein Larval abnormalities, Metallothionein produced Geffard et al., 2003
M. gigas PAHs (various) + heavy metals (Cd, Cu, Zn) + miscellaneous contaminants in sediment or elutriate Embryogenesis Larval growth Delayed blastula formation, Larval abnormalities Geffard et al., 2004
C. virginica PAHs + heavy metals + miscellaneous contaminants in sediment suspension Infection Immune function No significant difference in neutral red uptake by hemocytes, Increased tetrazolium dye reduction, Increased 3H-leucine incorporation, Significantly increased rate of Perkinsus infection Chu et al., 2002
C. virginica PAHs + miscellaneous contaminants in sediment Embryogenesis Larval development Fertilization inhibition, Embryo abnormalities, Reduction in shell growth Boulais et al., 2018
C. brasiliana PAHs + heavy metals + miscellaneous chemicals in coal tar-based paint Lysosomes Lysosomal destabilization Chiovatto et al., 2021

The contaminant mixtures are either derived from sediments collected from contaminated sites or from anthropogenic chemical products. This non-exhaustive list provides a collection of common end points used to study chemical toxicity and some of the effects of the contaminants that may manifest in a less controlled setting.