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. 2021 Sep 10;11:694186. doi: 10.3389/fcimb.2021.694186

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Copyright © 2021 Huckriede, de Vries, Hultström, Wichapong, Reutelingsperger, Lipcsey, Garcia de Frutos, Frithiof and Nicolaes

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histone H3 cleavage in COVID-19 patients. The fraction of patients with detectable cleaved or non-cleaved histone H3 (A). Western blot analysis using a polyclonal anti-histone H3 antibody allowed detection of proteolytic cleavage of histone H3, distinguishing between full-sized histone H3 (15 kDa) and a histone H3 fragment (12 kDa) (B). The concentration of histone H3 (C) or NE (D) in cleaved or non-cleaved histone H3 positive samples. The percentage (%) for the positive amount of significantly different clinical events during the stay at the ICU (E). Acute kidney injury (AKI). P-values were considered significant if p < 0.05; *0.05, **0.01, ***0.001.