Table 3.
Clinical characteristics of young-onset and late-onset patients with RR-MS.
| YORRMS | LORRMS | B–H adjusted p | ||
|---|---|---|---|---|
| Patients | N | 177 | 89 | |
| Age of onset (years) | Median (IQR) | 28.16 (23.13–32.93) | 47.37 (42.46–51.53) | – |
| Sex, F | N (%) | 117 (66.1) | 66 (74.2) | 0.211* |
| Disease duration, months | Median (IQR) | 3.71 (1.07–21.17) | 11.4 (1.7–37.6) | 0.11# |
| Unique CSF OCB, present | N (%) | 128/172 (74.4) | 62/89 (69.7) | 0.413* |
| EDSS | Median (IQR) | 1.5 (1–2) | 2 (1–2.5) | 0.11# |
| Clinical disease activity, yes | N (%) | 74/176 (42) | 20/87 (23) | 0.014* |
| Radiological disease activity, yes | N (%) | 79/170 (46.5) | 29/82 (35.4) | 0.133* |
| BREMS at onset | Median (IQR) | 0.02 (−0.6 to 0.53) | 0.07 (−0.5 to 0.76) | 0.038# |
*
p-value of the χ2 test;
#
p-value of the Mann–Whitney U test.
B–H, Benjamini–Hochberg; BREMSO, Bayesian risk estimate for MS at onset; CSF, cerebrospinal fluid; EDSS, Expanded Disability Status Scale; YORRMS, young-onset relapsing-remitting multiple sclerosis; LORRMS, late-onset relapsing-remitting multiple sclerosis; MS, multiple sclerosis; OCB, oligoclonal bands; RR, relapsing-remitting.