Table 2.
The predictive value of different aPLs in APS diagnosis.
| Sensitivity (%) | Specificity (%) | Accuracy(%) | Youden Index | PPV (%) | NPV (%) | OR (95% CI) | |
|---|---|---|---|---|---|---|---|
| aCL IgG | 37.09 | 100.00 | 60.58 | 0.371 | 100.00 | 48.65 | ∞ |
| aCL IgM | 8.61 | 97.78 | 41.90 | 0.064 | 86.67 | 38.94 | 4.15 (0.91–18.81) |
| aCL IgG or IgM | 41.06 | 97.78 | 62.24 | 0.389 | 96.88 | 49.72 | 30.65 (7.27–129.20) |
| aβ2GpI IgG | 23.18 | 100.00 | 51.86 | 0.232 | 100.00 | 43.69 | ∞ |
| aβ2GpI IgM | 7.95 | 98.89 | 41.91 | 0.068 | 92.31 | 39.04 | 7.68 (0.98–60.12) |
| aβ2GpI IgG or IgM | 29.14 | 98.89 | 55.19 | 0.28 | 97.78 | 45.41 | 36.60 (4.94–270.96) |
| aCL or aB2GpI IgG or IgM | 43.05 | 97.78 | 63.48 | 0.408 | 97.01 | 50.57 | 33.26 (7.89–140.10) |
| aCL IgA | 30.46 | 92.22 | 53.53 | 1.2268 | 86.79 | 44.15 | 5.19 (2.23–12.10) |
| aβ2GpI IgA | 6.62 | 98.89 | 41.08 | 1.0551 | 90.91 | 38.70 | 6.31 (0.79–50.16) |
| aCL IgG or IgM or IgA | 51.66 | 91.11 | 66.39 | 1.4277 | 90.70 | 52.90 | 10.95 (4.96–24.21) |
| aβ2GpI IgG or IgM or IgA | 31.79 | 97.78 | 56.43 | 1.2957 | 96.00 | 46.07 | 20.51 (4.85–86.79) |
| aCL or aB2GpI IgG or IgM or IgA | 53.64 | 91.11 | 67.63 | 91.01 | 53.95 | 11.86 (5.37–26.22) | |
| P1 | <0.001 | 0.031 | 0.052 | ||||
| P2 | 0.125 | 1.000 | 0.375 | ||||
| P3 | <0.001 | 0.031 | 0.052 | ||||
| aPS/PT IgG | 18.54 | 96.67 | 47.72 | 0.152 | 90.32 | 41.43 | 6.60 (1.95–22.40) |
| aPS/PT IgM | 7.28 | 98.89 | 41.49 | 0.062 | 91.67 | 38.86 | 6.99 (0.89–55.10) |
| aPS/PT IgG or IgM | 24.50 | 95.56 | 51.03 | 0.201 | 90.24 | 43.00 | 6.99 (2.40–20.32) |
| aCL, aB2GpI, or aPS/PT IgG or IgM | 45.70 | 94.44 | 63.90 | 0.401 | 93.24 | 50.90 | 14.31 (5.49–37.25) |
| P1’ | <0.001 | 0.625 | <0.001 | ||||
| P2’ | 0.167 | 0.375 | 0.064 | ||||
| P3’ | 0.125 | 0.250 | 1.000 | ||||
| aAnxV IgG | 30.46 | 100.00 | 56.43 | 0.305 | 100.00 | 46.15 | ∞ |
| aAnxV IgM | 16.56 | 96.67 | 46.47 | 0.133 | 89.29 | 40.85 | 5.75 (1.69–19.70) |
| aAnxV IgG or IgM | 39.07 | 96.67 | 60.58 | 0.358 | 95.16 | 48.60 | 18.60 (5.62–61.53) |
| aCL, aβ2GpI, or aAnxV IgG or IgM | 47.68 | 96.67 | 65.98 | 0.444 | 96.00 | 52.41 | 26.43 (8.01–87.26) |
| P1’’ | 0.648 | 1.000 | 0.503 | ||||
| P2’’ | <0.001 | 0.500 | 0.007 | ||||
| P3’’ | 0.016 | 1.000 | 0.070 |
PPV, positive predictive value; NPV, negative predictive value; OR, odds ratio; CI, confidence interval. p-values of sensitivity, specificity, and accuracy are calculated with McNemar test.
P1: Comparison of result of aCL IgG or IgM or IgA to aCL IgG or IgM; P2: Comparison of result of aβ2GpI IgG or IgM or IgA to aβ2GpI IgG or IgM; P3: Comparison of result of aCL or aβ2GpI IgG or IgM or IgA to aCL or aβ2GpI IgG or IgM; P1’: Comparison of result of aPS/PT IgG or IgM to aCL IgG or IgM; P2’: Comparison of result of aPS/PT IgG or IgM to aβ2GpI IgG or IgM; P3’: Comparison of result of aCL, aβ2GpI, or aPS/PT IgG or IgM to aCL or aβ2GpI IgG or IgM; P1’’: Comparison of result of aAnxV IgG or IgM to aCL IgG or IgM; P2’’: Comparison of result of aAnxV IgG or IgM to aβ2GpI IgG or IgM; P3’’: Comparison of result of aCL, aB2GpI, or aAnxV IgG or IgM to aCL or aβ2GpI IgG or IgM. Odds ratios (ORs) with 95% confidence intervals (CIs) are shown.
Bold values mean P < 0.05.