Table 1.
Clinical features of the patients’ cohort and predictors of mortality. Data describing clinical and serological features of the patients’ cohort are reported as median (interquartile range). Data describing univariate and multivariate analyses are reported as odds ratio. P value (significant difference < 0.05) considers the comparison between non-survivors and survivors.
| Total (N=128) | Survivors (n=98) | Non-survivors (n=30) | p value | OR | Univariate Analysis (p value) | OR | Multivariate Analysis (p value) | |
|---|---|---|---|---|---|---|---|---|
| Age (years) | 69 (57-81) | 64 (55-77) | 82.5 (73-86) | 0.0001 | 1.06 | 0.0001 | 1.05 | 0.02 |
| Sex (M) | 87 (67%) | 64 (65%) | 23 (23%) | 0.27 | 0.68 | 0.36 | ||
| Diabetes n (%) | 28 (21.9%) | 14 (14%) | 14 (47%) | 0.007 | 1.4 | 0.38 | ||
| Hypertension n (%) | 67 (52%) | 44 (45%) | 23 (77%) | 0.003 | 2.99 | 0.01 | 0.41 | 0.08 |
| PaO2/FiO2 (mmHg) | 275 (204-325) | 285 (260-335) | 204 (98-300) | 0.002 | 0.99 | 0.015 | 0.99 | 0.62 |
| ESR (< 20 mm/hr) | 69 (46-92) | 65 (42-77) | 95 (50-110) | 0.17 | 1.02 | 0.27 | ||
| CRP (< 6 mg/L) | 80 (42-150) | 70 (33-125) | 120 (62-195) | 0.004 | 1.01 | 0.002 | 1.01 | 0.001 |
| IL-6 (<10 pg/mL) | 37.35 (16-87.3) | 30.4 (10.4-75) | 67.3 (36.4-224) | 0.007 | 1 | 0.96 | ||
| IgG1 (3824-9286 mg/L) | 5294 (3961-6345) | 5294 (4007-6403) | 5338 (3872-6425) | 0.88 | 1 | 0.68 | ||
| IgG2 (2418-7003 mg/L) | 3625 (2702-4759) | 3639 (2675-4633) | 3481 (2824-5039) | 0.67 | 1 | 0.3 | ||
| IgG3 (218-760 mg/L) | 749 (502-1038) | 756 (491-1217) | 687 (487-840) | 0.34 | 0.99 | 0.19 | ||
| IgG4 (39-864 mg/L) | 352 (207-558) | 340 (195-471) | 426 (269-757) | 0.04 | 1 | 0.002 | NA | |
| IgG (8400-16000 mg/L) | 10026 (8837-12197) | 9014 (8156-11920) | 10032 (7611-13088) | 0.78 | 1 | 0.73 | ||
| IgG4/IgG | 0.03 (0.02-0.05) | 0.03 (0.02-0.05) | 0.05 (0.03-0.08) | 0.007 | 1.01 | 0.04 | NA | |
| IgG4/IgG1 | 0.06 (0.04-0.11) | 0.06 (0.04-1) | 0.07 (0.05-0.17) | 0.012 | 2406 | 0.0001 | 292.5 | 0.01 |
Abbreviations: erythrocyte sedimentation rate (ESR); C-reactive protein (CRP); interleukin-6 (IL-6); Odds ratio (OR).