Figure 1.

Cartoon depicting the proposed mechanisms that regulate the cancer secretome and favor neutrophil trafficking to tumors. Cancer associated EMT program activation alters cancer cell secretome by inducing the expression of neutrophil recruiting mediators. Three machineries, namely exocytic trafficking, secretory autophagy, and extracellular vesicles are proposed to enhance the release of neutrophil recruiting mediators from cancer cells. The secreted mediators promote EMT using a feed forward mechanism and initiate a chronic cycle of inflammation that supports cancer cell dissemination. TFs, transcription factors; RE, recycling endosome.