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. 2021 Sep 10;9:690397. doi: 10.3389/fcell.2021.690397

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Copyright © 2021 Bertolio, La Colla, Carrea, Romo, Canziani, Echarte, Campisano, Barletta, Monzon, Rodríguez, Chisari and Dewey.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TβRII-SE/Fc overexpression prevents CCl₄-induced liver fibrosis development and HSC activation. (A) Representative images of liver sections stained with either H&E (top panel), Sirius Red (middle panel), and α-SMA immunohistochemistry of animals treated with vehicle, CCl₄, Lv.TβRII-Fc + CCl₄, or Lv.TβRII-SE/Fc + CCl₄. Original magnification × 40. (B) Quantification of both liver Sirius Red positive areas (SR⁺) (left panel) and liver α-SMA⁺ expression (right panel) in the same experimental groups. Results are expressed as mean intensity of SR⁺ area. *p < 0.05, Vehicle vs. CCl₄, or CCl₄ vs. Lv.TβRII-SE/Fc + CCl₄. HSC, hepatic stellate cells; H&E, hematoxylin and eosin; α-SMA; alpha-smooth muscle actin.