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. 2021 Sep 10;12:729359. doi: 10.3389/fimmu.2021.729359

Figure 5.

Figure 5

Tumor genomic alterations associated with IFNGrGS-based stratification. (A) The top 10 mutated genes in the IFNGrGS score-high and -low groups based on the somatic mutation file ‘mutect’. (B) DMGs in the IFNGrGS score-high and -low groups based on 4 somatic callers using Fisher’s exact test. (C) The mutation type and frequency of TRPM2, CDH9, EGFR, and RYR2 based on the ‘mutect’ file. (D) Co-occurring and mutually exclusive gene pairs. Upper panel: the IFNGrGS score-high group, and lower panel: the IFNGrGS score-low group. (E) The association between the IFNGrGS score and IDH, ATRX, and PTEN gene mutation, and the tumor purity. *p < 0.05, **p < 0.01, ***p < 0.001, and ns, non-significant.