Table 3.

Early-life adversities and risk of all-cause mortality (HR (95% CI)) in adults (44/45–58 years) adjusted for mid-adult (1) socioeconomic, (2) behavioural, (3) adiposity, (4) mental health and (5) cardiometabolic factors* (N=9310)

	Socioeconomic disadvantage	Neglect	Physical abuse	Sexual abuse
Model 3	1.93 (1.45 to 2.58)	1.43 (1.03 to 1.98)	1.73 (1.11 to 2.71)	2.64 (1.52 to 4.59)
+mid-adult socioeconomic factors	1.82 (1.36 to 2.43)	1.28 (0.91 to 1.79)	1.74 (1.11 to 2.73)	2.54 (1.46 to 4.42)
+mid-adult behavioural factors	1.75 (1.31 to 2.34)	1.32 (0.95 to 1.83)	1.50 (0.96 to 2.34)	2.43 (1.40 to 4.23)
+mid-adult adiposity	1.90 (1.42 to 2.53)	1.39 (1.00 to 1.93)	1.75 (1.12 to 2.73)	2.71 (1.56 to 4.73)
+mid-adult mental health	1.91 (1.43 to 2.55)	1.37 (0.99 to 1.91)	1.70 (1.09 to 2.64)	2.54 (1.46 to 4.42)
+mid-adult cardio-metabolic factors	1.89 (1.42 to 2.53)	1.39 (1.00 to 1.93)	1.65 (1.05 to 2.57)	2.71 (1.56 to 4.72)

Model 3 (adjustments shown in figure 1 footnotes).

*Models were adjusted for each intermediary group of factors separately (not simultaneously). See details of intermediary factors in online supplemental table S1.