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. 2021 Sep 10;12:707211. doi: 10.3389/fimmu.2021.707211

Table 2.

Targets in clinical trials in solid tumor CAR-T therapy.

Antigen Tumors ID
HER2 Central nervous system tumor, pediatric glioma NCT03500991
Nectin4/FAP Nectin4-positive advanced malignant solid tumor NCT03932565
EGFR806 Central nervous system tumor, pediatric glioma NCT03179012
Mesothelin Ovarian, cervical, pancreatic, lung NCT01583686
Lewis Y Advanced cancer NCT03851146
LMP1 Nasopharyngeal NCT02980315
FR-α Ovarian NCT00019136
EGFRIII Glioblastoma and brain tumor NCT01454596
Glypican-3 Liver NCT02932956
PSCA Lung NCT03198052
MUC1 Advanced solid tumors, lung NCT03179007, NCT03525782
IL-13Rα2 Glioblastoma NCT02208362
MAGE-A1/3/4 Lung NCT03356808, NCT03535246
gp100 Melanoma NCT03649529
Claudin 18.2 Advanced solid tumor NCT03874897
EpCAM Colon, pancreatic, prostate, gastric, liver NCT03013712
PSMA Prostate NCT01140373
AXL Renal NCT03393936
CD171 Neuroblastoma NCT02311621
CD20 Melanoma NCT03893019
MUC16 Ovarian NCT02311621
DR5 Hepatoma NCT03638206
c-MET Breast, hepatocellular NCT03060356, NCT03638206
CD80/86 Lung NCT03198052
DLL-3 Lung NCT03392064